|
Symbol Name ID |
Txnrd1
thioredoxin reductase 1 MGI:1354175 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Neurodegeneration |
Fasciculations |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Atypical behavior |
Agitation |
Cognitive impairment |
Frontotemporal dementia |
Sleep abnormality |
Hyperreflexia |
Jaw hyperreflexia |
| Disease(s) Associated with TXNRD1 | |||||||||||||||||||||||
| amyotrophic lateral sclerosis |
| Mouse Phenotypes | nervous system phenotype |
abnormal neural tube morphology |
abnormal cerebellum development |
abnormal cerebellar lobule formation |
thin external granule cell layer |
abnormal cerebellum morphology |
abnormal cerebellar cortex morphology |
abnormal Purkinje cell dendrite morphology |
ectopic Purkinje cell |
cerebellum hypoplasia |
abnormal glial cell morphology |
abnormal astrocyte morphology |
|
| Availability | Mouse Genotype | ||||||||||||
| Txnrd1tm1.1Marc/Txnrd1tm1.1Marc | |||||||||||||
| Txnrd1tm1Marc/Txnrd1tm1Marc Tg(Nes-cre)1Kln/0 (conditional) |
* | ||||||||||||
| Txnrd1tm1Marc/Txnrd1tm1Marc Tg(Tuba1-cre)1Tes/0 (conditional) |
* | ||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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